Sodium Hydroxide → HCID 57268046, compound

Participants

Reaction Conditions

Reaction Steps

450 mg of K3Fe(CN)6 is dissolved in 1.8 ml of water, mixed with 1.4 ml of 1N NaOH and cooled to 4° C. 200 mg of 4-ethyl-6-thioacetylamino-β-carboline-3-carboxylic acid isopropyl ester in 4 ml of pyridine is added in drops to this solution and stirred for another 2 hours at this temperature. The reaction mixture is taken up in ethyl acetate, washed with water, dried and concentrated by evaporation. The residue is chromatographed on silica gel with toluene+ethanol=95+5. The desired fractions are concentrated by evaporation and stirred up with ether. 30 mg of the title compound with a melting point of 239-240° C. is obtained.

Provenance & Evidence