反应详情

To a 100 ml round-bottomed flask with condenser and nitrogen inlet were added 1.0 gram (3.88 mmol) of 6-(2-bromoethyl)benzothiazolone, 822 mg (3.88 mmol) N-(1-naphthyl)piperazine, 410 mg (3.88 mmol) sodium carbonate, and 50 ml methylisobutlyketone. The reaction was refluxed for 24 hours, cooled, and evaporated. The residue was taken up in ethyl acetate, washed with water and brine, dried over sodium sulfate, and evaporated. The resulting solid was treated with hot ethyl acetate to afford a white solid, m.p. 198°-220° C., 540 mg (36%).

1. temperatureThe reaction was refluxed for 24 hours
2. temperaturecooled
3. customevaporated
4. washwashed with water and brine
5. dry with materialdried over sodium sulfate
6. customevaporated
7. additionThe resulting solid was treated with hot ethyl acetate
8. customto afford a white solid, m.p. 198°-220° C., 540 mg (36%)