Potassium Hydroxide → HCID 136333712, compound

Participants

Reaction Steps

2.68 g of (+/-)-cis-6-(4-acetoxyphenyl)-8,9-diethoxy-1,2,3,4,4a,10b-hexahydrophenanthridine are dissolved in 15 ml of methanol, treated with 1.1 g of potassium hydroxide and the mixture is stirred at RT for 2 h. After removal of the solvent in vacuo, the residue is taken up in water, rendered neutral and extracted with ethyl acetate. The organic phase is dried using sodium sulfate and the solvent is removed in vacuo. 1.23 g (51.2% of theory) of the title compound of m.p. 232-234° C. are obtained.

Provenance & Evidence