Water → HCID 18665742, compound

HRID 365456Notes

Reaction equation

HRID 365456 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)([OH:20])[CH2:8][N:9]1[CH2:14][CH2:13][CH2:12][C@H:11]([C:15]([O:17]CC)=[O:16])[CH2:10]1.[OH-].[Na+].O>CCO>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)([OH:20])[CH2:8][N:9]1[CH2:14][CH2:13][CH2:12][C@H:11]([C:15]([OH:17])=[O:16])[CH2:10]1

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 18665754HCID 18665754, compound

Product 1

HCID 18665742HCID 18665742, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 1-[2-(2-pyridyl)-2-phenyl-2-hydroxyethyl]piperidine-3(S)-carboxylate (0.187 g, 0.527 mmol) was dissolved in EtOH (5 mL), 1N NaOH (0.791 mL, 0.791 mmol) and H2O (5 mL) added, and the reaction mixture heated at reflux for 3 hr. Neutralization with 1N HCl (to a pH of 6) and concentration to dryness gave the title compound which was used without further purification.

Workup

  1. temperaturethe reaction mixture heated
  2. temperatureat reflux for 3 hr
  3. concentrationNeutralization with 1N HCl (to a pH of 6) and concentration to dryness

Sources & evidence

ORD record
ord-a73be071fc2047dbad6814e254902f73
Source dataset
uspto-grants-2000_10
Patent number
US06127366

Reaction notes

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