Methanol → HCID 54248970, compound

Participants

Reaction Conditions

Reaction Steps

7 ml (7 mmol) of a molar solution of BH3 /THF are added, dropwise and with vigorous stirring, to a solution, maintained under nitrogen, of 1.20 g (2.70 mmol) of the compound obtained in Step 3 (diastereoisomer 1) in 30 ml of anhydrous THF. The mixture is then heated at 70° C. for 1 hour and is then cooled, treated with 8 ml of CH3OH and stirred at 20° C. for 1 hour. After concentrating in vacuo, the residue is chromatographed on silica, eluting with a solution of CH2Cl2 /CH3OH=95/5, to yield the title compound in the form of an oil.

Provenance & Evidence