Isopropanol → HCID 17800145, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 16 g of the compound obtained in Step 1 in 200 ml of THF is added dropwise to a suspension, maintained under nitrogen, of 2.28 g (60 mmol) of LiAlH4 in 200 ml of THF. The temperature of the mixture is then increased to 20° C. and stirring is maintained at that temperature for 3 hours. The mixture is again cooled to 0° C. and hydrolysed by successive additions of 20 ml of iPrOH and 25 ml of saturated NaCl solution. The precipitate formed is suctioned off and rinsed with THF; the filtrate is concentrated in vacuo and the residue is chromatographed on silica, eluting with a mixture of CH2Cl2 /CH3OH/NH4OH=97/3/0.3, to yield the title compound in the form of 2 diastereoisomers:

Provenance & Evidence