HCID 23292346, compound → HCID 23292352, compound

Participants

Reaction Steps

A suspension of 0.50 g (1.55 mmol) of the compound obtained in Step 3 and 0.14 g of Pd(OH)2 in a mixture of 0.8 ml of acetic acid and 50 ml of EtOH is hydrogenated at 20° C. under 1 bar for 20 hours. After filtration of the mixture and concentration in vacuo, the residue is taken up in 1N aq. NaOH (10 ml) and extracted with CH2Cl2 (3×10 ml); the combined organic phases are washed with saturated aq. NaCl, dried and concentrated to yield the title compound in the form of an oil, which is used in the following reaction without being otherwise purified.

Provenance & Evidence