Potassium Hydroxide → HCID 23291945, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 4-[(1-isopropyl-4,4-dimethyl-1,2,3,4-tetrahydroquinolin-6-yl) (3-methylbutyl)amino]benzoate (Compound 13, 20 mg, 0.05 mmol) was dissolved in ethanol (4.0 mL) and the solution treated with 1.4 M KOH (1.0 mL). The solution was heated to 40° C. and stirred for 24 hours. The solution was cooled and concentrated under reduced pressure. The residue was diluted with water, acidified with 10% HCl, and extracted with ethyl acetate (2×). The combined organic layers were washed with brine, dried (MgSO4), filtered and concentrated under reduced pressure to give the title compound (15 mg, 79%) as a solid.

Provenance & Evidence