2-[(Trifluoroacetyl)amino]benzamide → 2-(Trifluoromethyl)-3,4-dihydroquinazolin-4-one

HRID 36558Notes

Reaction equation

HRID 36558 reaction equation
[F:1][C:2]([F:16])([F:15])[C:3]([NH:5][C:6]1[CH:14]=[CH:13][CH:12]=[CH:11][C:7]=1[C:8]([NH2:10])=[O:9])=O>C(O)CO>[F:1][C:2]([F:16])([F:15])[C:3]1[NH:10][C:8](=[O:9])[C:7]2[C:6](=[CH:14][CH:13]=[CH:12][CH:11]=2)[N:5]=1

Participants

3

Reactant 1

HCID 7728532-[(Trifluoroacetyl)amino]benzamide

Product 1

HCID 1354155312-(Trifluoromethyl)-3,4-dihydroquinazolin-4-one

Reagents, catalysts & solvents 1

HCID 174Ethylene GlycolSolvent

Procedure

(Trifluoroacetamido)benzamide (73.0 g, 0.31 mole) was heated in ethylene glycol (150 ml) in an oil bath with stirring. The amide dissolved at around 130° and product began to precipitate out at 150°. The temperature was held at 150° for a further 1 hour before cooling. The solid was filtered off washing well with cold water to give the product, 55.7 g (84%).

Workup

  1. customto precipitate out at 150°
  2. temperaturebefore cooling
  3. filtrationThe solid was filtered off
  4. washwashing well with cold water
  5. customto give the product, 55.7 g (84%)

Sources & evidence

ORD record
ord-bfa8134c6fa248d7833d2af504c616c4
Source dataset
uspto-grants-1995_05
Patent number
US05415981

Reaction notes

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