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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 365676Generated: October 26, 2026

1-Hydroxybenzotriazole → piperidine N,N-dimethylformamide

https://huagongshe.com/reaction/365676

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-HydroxybenzotriazoleHCID 75771—
ReactantDiisopropylethylamineHCID 81531—
SolventN-methyl-2-pyrrolidoneHCID 13387—
Productpiperidine N,N-dimethylformamideHCID 23501187—

Reaction Steps

125 ml of 2.6 g Bop/1-methyl-2-pyrrolidone +1.7 ml of DIEA +0.8 g of HOBt (15 hours, two times)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06127519
Source datasetuspto-grants-2000_10
ORD IDord-8aaecd5f6ac64646b1fa047fffa1fc7c
Source noteuspto-grants-2000_10