Sulfuryl chloride → 4-Bromoacetyl-2-geranyloxy-2,3,4,5-tetrahydro-1,4-benzothiazepine

Participants

Reaction Steps

The above-mentioned 4-bromoacetyl-2,3,4,5-tetrahydro-1,4-benzothiazepine (2.5 g) and sulfuryl chloride (1.5 g) were reacted in the same manner as in Experimental Example 7 to give 4-bromoacetyl-2-chloro-2,3,4,5-tetrahydro-1,4-benzothiazepmne (1.4 g). This compound (0.30 g), geraniol (0.30 g) and zinc chloride (0.26 g) were reacted in the same manner as in Experimental Example 9 to give 4-bromoacetyl-2-geranyloxy-2,3,4,5-tetrahydro-1,4-benzothiazepine (0.21 g). Then, this compound (0.21 g), 4-benzyl piperidine (O.11 g) and potassium carbonate (0.13 g) were reacted in the same manner as in Experimental Example 6 to give 4-[1-(4-benzyl) piperidinyl]acetyl-2-geranyloxy-2,3,4,5-tetrahydro-1,4-benzothiazepine (0.26 g).

Provenance & Evidence