Anisole → 4-Bromoacetyl-7-methoxy-2-(4-methoxyphenyl)-2,3,4,5-tetrahydro-1,4-benzothiazepine

Participants

Reaction Steps

The above-mentioned 4-bromoacetyl-2-chloro-7-methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine (0.19 g), anisole (0.07 g) end stannic chloride (0.17 g) were reacted in the same manner as in Experimental Example 13 to give 4-bromoacetyl-7-methoxy-2-(4-methoxyphenyl)-2,3,4,5-tetrahydro-1,4-benzothiazepine (0.17 g). This compound (0.1g), 4-benzyl piperidine (0.09 g) and potassium carbonate (0.11 g) were reacted in the same manner as in Experimental Example 6 to give 4-[1-(4-benzyl)piperidinyl]acetyl-7-methoxy-2-(4-methoxyphenyl)-2,3,4,5-tetrahydro-1,4-benzothiazepine (0.20 g).

Provenance & Evidence