HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Sulfate → 7-Methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Sulfate | HCID 24436 | — |
| Reactant | 7-Methoxy-3,4-dihydrobenzo[f][1,4]thiazepin-5(2H)-one | HCID 11287261 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 7-Methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine | HCID 11805628 | 94.3% |
Reaction Steps
Aluminum lithium hydride (2.739) and the abovementioned 7-methoxy-5-oxo-2,3,4,5-tetrahydro-1,4-benzothiazepine (5.0 g) were added to THF (150 ml) under ice cooling and heated at reflux for 3 hours. After adding an excess amount of sodium sulfate.10 hydrates, a celite filtration was made. The resulting filtrate was concentrated to give 7-methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine (4.4 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05416066 |
| Source dataset | uspto-grants-1995_05 |
| ORD ID | ord-8b5de020a416400d905809c3a15a3aa5 |
| Source note | uspto-grants-1995_05 |