4-Fluorobenzonitrile → 4-(Thiomorpholin-4-yl)benzonitrile

HRID 365737Notes

Reaction equation

F[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[NH:10]1[CH2:15][CH2:14][S:13][CH2:12][CH2:11]1>>[S:13]1[CH2:14][CH2:15][N:10]([C:2]2[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=2)[CH2:11][CH2:12]1

Participants

Reactant 2

HCID 145174-Fluorobenzonitrile

HCID 67164Thiomorpholine

Product 1

HCID 232929824-(Thiomorpholin-4-yl)benzonitrile

Procedure

According to a similar manner to that in Reference Example 12, the title compound was synthesized from 4-fluorobenzonitrile and thiomorpholine.

Sources & evidence

ORD record: ord-860a0e05136e4e758b716c635f809c16
Source dataset: uspto-grants-2000_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06127541

Reaction notes

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