HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxybenzaldehyde → Methyl 1,2,3,4-tetrahydro-1-(4-hydroxyphenyl)-9h-pyrido(3,4-b)indole-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxybenzaldehyde | HCID 126 | — |
| Reactant | L-Tryptophan, ethyl ester | HCID 81996 | — |
| Product | Methyl 1,2,3,4-tetrahydro-1-(4-hydroxyphenyl)-9h-pyrido(3,4-b)indole-3-carboxylate | HCID 11186332 | — |
Reaction Steps
The same method but starting from racemic tryptophan ethyl ester and 4-hydroxybenzaldehyde gave the title compound as pale yellow crystals 1H NMR (DMSO) δ (ppm): 10.3 (s, 1H, NH-indole) 9.4 (s, 1H, OH); 7.8-7.5 (m, 8H, H aromatic); 5.1 (brs, 1H, H-1); 3.9 (m, 1H, H-3); 3.75 (s, 3H, CO2CH3) 3.1 (m, 1H, H-4); 2.8 (m, 1H, H-4).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06127542 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-4bf31d65fb83436e859b153751a745ff |
| Source note | uspto-grants-2000_10 |