反应详情

A solution of ethyl 2,2-difluoro-3-tetrahydropyranyloxypropionate (3.5 g, 15 mmol) in absolute ethanol (10 ml) was added dropwise to a slurry of sodium borohydride (0.57 g, 15 mmol) at room temperature in absolute ethanol (20 ml). Then the mixture was stirred an additional hour at room temperature. Then the mixture was concentrated in vacuo, hydrolyzed with aqueous ammonium chloride, extracted with ethyl acetate and dried over magnesium sulfate. The product was purified by flash chromatography on silica gel (ethyl acetate:hexane; 25:75) (2.7 g, 90%).

1. concentrationThen the mixture was concentrated in vacuo, hydrolyzed with aqueous ammonium chloride
2. extractionextracted with ethyl acetate
3. dry with materialdried over magnesium sulfate
4. customThe product was purified by flash chromatography on silica gel (ethyl acetate:hexane; 25:75) (2.7 g, 90%)