Hydrochloric Acid → HCID 69830758, compound

Participants

Reaction Steps

To a solution of 5-octynyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine from step b above in Et2O was added hydrogen chloride (1.0 M in Et2O) carefully to afford the tittle compound: 1H NMR (D2O) δ0.87 (t, 3H, J=7.0 Hz), 1.32 (t, 4H, J=4.0 Hz), 1.45 (t, 2H, J=7.0 Hz), 1.96 (m, 1H), 2.02-2.20 (m, 2H), 2.29 (m, 1H), 2.49 (t, 2H, J=7.0 Hz), 3.41 (t, 2H, J=7.0 Hz), 4.14 (m, 1H), 4.33 (dd, 1H, J=7.5, 11.0 Hz), 4.54 (dd, 1H, J=3.5, 11.0 Hz), 7.90 (t, 1H, J=1.5 Hz), 8.37 (t, 2H, J=3.0 Hz); MS (CI/NH3) m/z 287 (M+H)+. Anal. Calcd for C18H26N2O·1.7 HCl: C, 62.06; H, 8.01; N, 8.04. Found: C, 62.03; H, 7.99; N, 7.74. [α]25D+7.0 (c 0.88, MeOH).

Provenance & Evidence