Hydrochloric Acid → HCID 69830089, compound

Participants

Reaction Steps

To a solution of 5-ethenyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine from step b above in Et2O was added hydrogen chloride (1.0 M in Et2O) carefully to afford the tittle compound: mp 97° C. (dec). 1H NMR (D2O) δ 1.97 (m, 1H), 2.04-2.20 (m, 2H), 2.30 (m, 1H), 3.42 (t, 2H, J=7.0 Hz), 4.17 (m, 1H), 4.40 (dd, 1H, J=7.5, 10.5 Hz), 4.61 (dd, 1H, J=3.5, 10.5 Hz), 5.70 (d, 1H, J=11.0 Hz), 6.13 (d, 1H, J=17.5 Hz), 6.85 (dd, 1H, J=11.0, 17.5 Hz), 8.15 (t, 1H, J=3.0 Hz), 8.39 (d, 1H, J=2.5Hz), 8.48 (s, 1H). MS (CI/NH3) m/z 205 (M+H)+. Anal. Calcd for C12H16N2O.2 HCl: C, 52.00; H, 6.55; N, 10.11. Found: C, 52.22; H, 6.42; N, 9.87. [α]25D +22.5 (c 0.68, MeOH).

Provenance & Evidence