Hydrochloric Acid → HCID 22961861, compound

Participants

Reaction Steps

To a solution of 3-(2-(S)-azetidinylmethoxy)-6-chloro-5-ethenylpyridine from step b above in Et2O was added hydrogen chloride (1.0 M in Et2O) carefully to afford the tittle compound: mp 121° C. (dec); 1H NMR (D2O) δ 2.70 (q, 2H, J=8.5 Hz), 4.03-4.21 (m, 2H), 4.45 (d, 2H, J=4.0 Hz), 4.96 (m , 1H), 5.60 (d, 1H, J=11.0 Hz), 5.94 (d, 1H, J=17.0 Hz), 7.01 (dd, 1H, J=11.0, 17.5 Hz), 7.74 (d, 1H, J=3.0 Hz), 8.05 (d, 1H, J=3.0 Hz); MS (CI/NH3) m/z 225 (M+H)+, 242 (M+NH4)+. Anal. Calcd for C11H13CIN2O.1.1 HCl: C, 49.90; H, 5.37; N, 10.58. Found: C, 49.84; H, 5.25; N, 10.27. [α]25D -9.9 (c 2.0, MeOH).

Provenance & Evidence