Hydrochloric Acid → HCID 22961852, compound

Participants

Reaction Steps

To a solution of 3-(2-(S)-azetidinylmethoxy)-5-(5-pyrimidinyl)pyridine from step b above in Et2O was added hydrogen chloride (1.0 M in Et2O) carefully to afford the tittle compound: mp 185° C. (dec); 1H NMR (D2O) δ 2.64-2.78 (m, 2H), 3.59 (m, 1H), 4.08-4.22 (m, 2H), 4.52 (d, 1H, J=4.0 Hz), 4.97 (m, 1H), 7.84 (m, 1H), 8.36 (m, 1H), 8.93 (d, 1H, J=8.5 Hz), 9.11 (d, 1H, J=2.0 Hz), 9.17 (d, 1H, J=17.5 Hz); MS (CI/NH3) m/z 243 (M+H)+. Anal. Calcd for C13H14N4O.2 HCl.H2O: C, 46.86; H, 5.44; N, 16.81. Found: C, 47.08; H, 5.50; N, 16.79. [α]25D -6.32 (c 0.56, MeOH).

Provenance & Evidence