Hydrochloric Acid → HCID 22961891, compound

Participants

Reaction Steps

To a solution of 5-allyl-3-(2-(S)-azetidinylmethoxy)-6-chloropyridine in Et2O was added hydrogen chloride (1.0 M in Et2O) carefully to afford the tittle compound: mp 90-92° C.; 1H NMR (D2O) δ 2.70 (q, 2H, J=8.5 Hz), 3.52 (d, 2H, J=6.5 Hz), 4.02-4.20 (m, 2H), 4.42 (d, 1H, J=4.0 Hz), 4.93 (m, 1H), 5.08-5.22 (m, 2H), 5.99 (m, 1H), 7.50 (d, 1H, J=3.0 Hz), 8.05 (d, 1H, J=3.0 Hz); MS (CI/NH3) m/z 239 (M+H)+. Anal. Calcd for C12H15ClN2O.1.4 HCl: C, 49.74; H, 5.70; N, 9.67. Found: C, 49.99; H, 5.78; N, 9.41. [α]25D -6.9 (c 0.6, MeOH).

Provenance & Evidence