Hydrochloric Acid → HCID 88014372, compound

Participants

Reaction Steps

To a solution of 5-allyl-3-(1-BOC-2-(R)-pyrrolidinylmethoxy)6-chloropyridine in Et2O was added hydrogen chloride (4.0 M in 1,4-dioxane) carefully to afford the tittle compound: mp 90-92° C.; 1H NMR (D2O) δ 1.92 (m, 1H), 2.02-2.20 (m, 2H), 2.27 (m, 1H), 3.40 (t, 2H, J=7.0 Hz), 3.49 (d, 2H, J=6.5 Hz), 4.11 (m, 1H), 4.21 (dd, 1H, J=7.5, 10.5 Hz), 4.43 (dd, 1H, J=3.5, 10.5 Hz), 5.10 (dd, 1H, J=1.5, 17.0 Hz), 5.18 (dd, 1H, J=2.0, 10.0 Hz), 6.03 (m, 1H), 7.44 (d, 1H, J=3.0 Hz), 7.98 (d, 1H, J=3.0 Hz); MS (CI/NH3) m/z 253 (M+H)+. Anal. Calcd for C13H17ClN2O.2 HCl.0.8 H2O: C, 45.91; H, 6.11; N, 8.24. Found: C, 45.90; H, 6.36; N, 8.20. [α]25D -11.2 (c 1.4, MeOH).

Provenance & Evidence