HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tri(butyl)vinylstannane → 6-Methyl-5-vinyl-3-(1-t-butyloxycarbonyl-(2S)-azetidinylmethoxy)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tri(butyl)vinylstannane | HCID 21115800 | — |
| Reactant | 3-(1-BOC-2-(S)-azetidinylmethoxy)-5-bromo-6-methyl-pyridine | HCID 22961817 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | 6-Methyl-5-vinyl-3-(1-t-butyloxycarbonyl-(2S)-azetidinylmethoxy)pyridine | HCID 22961819 | 56.4% |
Reaction Steps
The product of 196e (1.0 g, 2.8 mmol) and tributylvinyl tin hydride (0.98 mL, 3.4 mmol) and tetrakis(triphenylphosphine)palladium (161 mg, 0.14 mmol) were as in Example 191a to provide the title compound (0.48 g, 1.58 mmol, 56%) after chromatography (silica gel; hexanes/EtOAc, 4:1): MS (CI/NH3) 305 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06127386 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-ef41156a15c44f7f9cab134ec80d8311 |
| Source note | uspto-grants-2000_10 |