Hydrochloric Acid → HCID 69830962, compound

Participants

Reaction Steps

To 3-(1-BOC-2-(S)-pyrrolidinylmethoxy)-5-methoxyethoxypyridine from step 197e (480 mg, 1.36 mmol) in CH2Cl2 at 0° C. was added a solution of HCl in Et2O, and the solution was stirred for 2 h. The solvent was removed and the residue was recrystallized from EtOH/Et2O to afford the title compound (215 mg): mp 182-184° C.; [α]25D +22.8° (c 0.56, MeOH); 1H NMR (D2O, 300 MHz) δ 1.98 (m, 1H), 2.00-2.06 (m, 2H), 2.25 (m, 1H), 3.00 (m, 1H), 3.05 (s, 3H), 3.65 (t, 2H, J=6.0 Hz), 3.85 (t, 2H, J=6.0 Hz), 4.15 (m, 1H), 4.30-4.35 (m, 2H), 4.52 (m, 1H), 7.15 (t, 1H, J=3.0 Hz), 8.02 (br s, 2H); MS (CI/NH3) m/z 253 (M+H)+, 279 (M+NH4)+ ; Anal. Calcd for C13H20N2O3.2.1 HCl: C, 47.48; H, 6.77; N, 8.52. Found: C, 47.56; H, 6.83; N, 8.51.

Provenance & Evidence