Acetic Anhydride → HCID 22961877, compound

Participants

Reaction Steps

5-Aminomethyl-3-(1-BOC-2-(S)-azetidinylmethoxy)-6-chloropyridine (0.19 g, 0.60 mmol) from Example 92b was treated with acetic anhydride and further processed according to the procedure of Example 205c to afford the title compounds in 76% yield. 1H NMR (CDCl3, 300 MHz) δ 1.40 (s, 9H), 2.04 (s, 3H), 2.10-2.19 (m, 2H), 3.85 (t, J=7.5 Hz, 2H), 4.10 (dd, J=3.0, 10.5 Hz, 1H), 4.31 (m, 1H), 4.42-4.57 (m, 3H), 7.38 (d, J=3.0 Hz, 1H), 8.04 (d, J=3.0 Hz, 1H); MS (CI/NH3) m/z 370 (M+H)+.

Provenance & Evidence