Hydrochloric Acid → HCID 22961864, compound

Participants

Reaction Steps

The product of step 213a (0.20 g, 0.50 mmol) was deprotected and isolated as the free base in 64% yield according to the procedure of Example 20b, followed by conversion to the hydrochloride with HCl/Et2O. [α]D23 +21.67 (c 0.7, MeOH); 1H NMR (D2O, 300 MHz) δ 2.66 (dd, J=8.5, 16.5 Hz, 2H), 4.02-4.17 (m, 2H), 4.42 (d, J=4.0 Hz, 2H), 4.64 (s, 2H), 4.88 (m, 1H), 6.68 (dd, J=1.5, 5.5 Hz, 1H), 7.23 (dd, J=1.0, 3.5 Hz, 1H), 7.52 (d, J=3.0 Hz, 1H), 7.72 (d, J=1.5 Hz, 1H), 8.11 (d, J=2.5 Hz, 1H); MS (CI/NH3) m/z 322 (M+H)+. Anal. Calcd for C15H16ClN3O3.1.2 HCl.0.2 H2O: C, 48.81; H, 4.81; N, 11.38. Found: C, 48.70; H, 4.76; N, 11.03.

Provenance & Evidence