Water → HCID 54337430, compound

Participants

Reaction Steps

A suspension of 15 g (35.9 mmol) dibromochalcone ii in 150 mL dry MeOH (distilled from Mg metal) was heated to reflux. Freshly prepared 3N MeONa (2.49 g Na in 36 mL MeOH) was added dropwise, and stirring was continued for 30 min. The clear orange solution was cooled to room temperature, and poured into 100 mL water. The aqueous suspension was extracted with CH2Cl2 and the solvent was removed under reduced pressure. The oily orange residue crystallized in part, and was used for the next reaction without further purification.

Provenance & Evidence