Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 2-Acetoxy-5-bromo-6-methylbenzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Acetic Anhydride | HCID 7918 | — |
| 반응물 | 3-Bromo-6-hydroxy-2-methylbenzoic acid | HCID 11053451 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 2-Acetoxy-5-bromo-6-methylbenzoic acid | HCID 11011149 | — |
반응 단계
A mixture of 1B (6.93 g, 30 mmol), acetic anhydride (3.5 ml, 36 mmol) and pyridine (15 ml) is heated under reflux with stirring for 16 hours. The reaction mixture is diluted with water and ethyl acetate. The organic phase is acidified with dilute hydrochloric acid and washed with water twice. The organic phase is concentrated in vacuo and the residue is purified by flash chromatography (dichloromethane:methanol, 9:1 v/v) yielding the pure product as a yellow oil, 7.4 g, (90.3%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06127570 |
| 출처 데이터셋 | uspto-grants-2000_10 |
| ORD ID | ord-53b724b373e640f3b1a2566c1fdb3d86 |
| 출처 메모 | uspto-grants-2000_10 |