反应详情

A mixture of 50B (5.1 g, 10.6 mmol), sodium carbonate (3.65 g), methanol (100 ml) and water (30 ml) is heated to reflux with stirring for 1 hour. The reaction mixture is diluted with water and extracted with ethyl acetate. The organic phase is separated and concentrated. The residue is recrystallized from petrol ethers/ethyl acetate (95:5 v/v) The pure product is obtained as yellowish crystals, 3.70 g (88.3%), mp. 119-120° C.

1. temperatureis heated
2. temperatureto reflux
3. extractionextracted with ethyl acetate
4. customThe organic phase is separated
5. concentrationconcentrated
6. customThe residue is recrystallized from petrol ethers/ethyl acetate (95:5 v/v) The pure product
7. customis obtained as yellowish crystals, 3.70 g (88.3%), mp. 119-120° C.