HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3,5-Trichlorobenzene → Ammonia
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3,5-Trichlorobenzene | HCID 7950 | — |
| Reactant | 1,3,5-Trifluorobenzene | HCID 9745 | — |
| Reactant | 3,5-Difluoroaniline | HCID 96595 | — |
| Product | Ammonia | HCID 222 | — |
| Product | 1,3,5-Trifluorobenzene | HCID 9745 | — |
| Product | 3,5-Difluoroaniline | HCID 96595 | — |
Reaction Steps
One embodiment of the present invention relates to the discovery that 3,5-difluoroaniline can be synthesized at high yields and high purity by fluorinating 1,3,5-trichlorobenzene in the presence of a polar solvent to make an intermediate 1,3,5-trifluorobenzene, and then aminating the 1,3,5-trifluorobenzene in the presence of aqueous or anhydrous ammonia to obtain the desired 3,5-difluoroaniline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06127577 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-4b08970ec16c4bdc8e67712613b25e80 |
| Source note | uspto-grants-2000_10 |