HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 365968Generated: October 25, 2026
Sulfuric Acid → 1-(o-Aminophenyl)-4-hydroxy-1-butanone
https://huagongshe.com/reaction/365968
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 2'-(Cyclopropylcarbonyl)-p-toluenesulfonanilide | HCID 23293245 | — |
| Product | 1-(o-Aminophenyl)-4-hydroxy-1-butanone | HCID 11206118 | 80% |
Reaction Steps
The product of example 2 (1.5 g, 4.7 mmol) is treated with 96% sulfuric acid and heated to 90° C. for 15 minutes. The solution is cooled, adjusted to pH 9 with ammonium hydroxide and extracted with methylene chloride. The combined extracts are concentrated in vacuo to provide 1-(o-aminophenyl)-4-hydroxy-1-butanone (80% yield, mp 58-61° C.). The product is identified by NMR and MS analyses.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06127576 |
|---|
| Source dataset | uspto-grants-2000_10 |
|---|
| ORD ID | ord-8c713a6fd62f4a74b4bcfd81d73ab546 |
|---|
| Source note | uspto-grants-2000_10 |
|---|
