HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 4-Ethynylphenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4'-Hydroxyacetophenone | HCID 7469 | — |
| Reactant | Phosphorus pentachloride | HCID 24819 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | Hydroxyphenylacetylene | HCID 10909551 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Ethynylphenol | HCID 32758 | 46% |
Reaction Steps
The conventional preparation process of hydroxyphenyl-acetylene has been reported, for example, in Izv. Akad. Nauk SSSR Se. r. Khim 1964(11), 2073-4. In the process, 4-hydroxyacetophenone is chlorinated with phosphorus pentachloride, reacted in liquid ammonia in the presence of metallic sodium and ammonium chloride, and successively treated with water to obtain 4-hydroxyphenylacetylene in 46% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06127583 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-d67d156f7ed84820974bbda2360448e5 |
| Source note | uspto-grants-2000_10 |