HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorodifluoromethane → 4-difluoromethoxy-pyrazolidine-N,N'-dicarboxylic acid di-tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorodifluoromethane | HCID 6372 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Di-tert-butyl 4-hydroxypyrazolidine-1,2-dicarboxylate | HCID 10334299 | — |
| Catalyst | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-difluoromethoxy-pyrazolidine-N,N'-dicarboxylic acid di-tert-butyl ester | HCID 53779472 | 33.3% |
Reaction Steps
0.2 g of tetrabutylammonium fluoride and 5.6 g of potassium hydroxide powder are added to a solution of 6.9 g of 4-hydroxy-pyrazolidine-N,N'-dicarboxylic acid di-tert-butyl ester in 60 ml of tetrahydrofuran. At a maximum of 45° C., 8.0 g of chlorodifluoromethane are introduced. The reaction solution is then filtered, concentrated and purified by means of column chromatography to yield 2.7 g of the desired product, 4-difluoromethoxy-pyrazolidine-N,N'-dicarboxylic acid di-tert-butyl ester, in the form of a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05416065 |
| Source dataset | uspto-grants-1995_05 |
| ORD ID | ord-ab3109325d83479eba6f59e9863eaba5 |
| Source note | uspto-grants-1995_05 |