Diethyl Ether → HCID 131722033, compound

Participants

Reaction Steps

Prepared according to the method described in Example 1(d) above from (R)-N5 -(Cbz)-(S)-N-[1-(4-methoxyphenyl)ethyl]ornithine amide hydrochloride (13.3 g; 30.5 mmol; from step (b) above) 2-nitrophenyl diphenyl acetate (9.8 g; 30.5 mmol; see Example 1(c) above), triethylamine (4.6 g; 45.8 mmol) and CH2Cl2 (600 mL), 60 hours reaction time. The reaction mixture was submitted to aqueous work up, dried, filtered and concentrated to give the crude product as a solid. The product was dissolved in CH2Cl2 and concentrated until solids began to form. Diethyl ether was added to precipitate more solids. The solids were collected and dried to give the sub-title compound as a white solid (13.5 g).

Provenance & Evidence