Triethylamine → HCID 178462148, compound

Participants

Reaction Steps

Prepared according to the method described in Example 2(f) above from (R)-N2 -(diphenylacetyl)-(S)-N-[1-(4-bromophenyl)ethyl]ornithine amide (free base; 0.20 g; 0.39 mmol; from step (d) above), 1H-pyrazole-1-carboxamidine mono hydrochloride (0.06 g; 0.39 mmol), triethylamine (0.08 g; 0.78 mmol; instead of DiPEA) and dimethyl formamide (1 mL), 5 hours reaction time. The solution was concentrated under vacuum and the crude product chromatographed on silica gel eluting with MeOH:CHCl3 :ammonium hydroxide (3:6:1). Conversion of the eluted compound to the hydrochloride salt gave the title compound as a white solid (0.17 g).

Provenance & Evidence