Triethylamine → HCID 178462147, compound

Participants

Reaction Steps

Prepared according to the method described in Example 2(f) above from (R)-N2 -(diphenylacetyl)-(R)-N-[1-(4-bromophenyl)ethyl]ornithine amide (free base, 0.42 g; 0.83 mmol; from step (d) above), 1H-pyrazole-1-carboxamidine mono hydrochloride (0.13 g; 0.83 mmol), triethylamine (0.17 g; 1.66 mmol; instead of DiPEA) and DMF (4 mL), 18 hours reaction time. The solution was concentrated under vacuum and the crude product chromatographed on silica gel using MeOH:CHCl3 :ammonium hydroxide (3:6:1). Conversion to the hydrochloride salt afforded the title compound as a white solid (0.31 g).

Provenance & Evidence