HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 178462150, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 178462144 | HCID 178462144 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 178462150 | HCID 178462150 | 99% |
Reaction Steps
Prepared according to the method described in Example 1(g) above from (R)-Nω,Nω '-bis(Cbz)-N2 -(diphenylacetyl)-(R)-N-(1-phenylethyl)arginine amide (0.6 g; 0.8 mmol; from step (d) above), 10% Pd/C (w/w; 200 mg), HOAc (25 mL), overnight reaction time. The crude acetate salt was converted to the hydrochloride to give 0.4 g (99%) of title compound as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06127414 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-f857a39d36a9420282585dd65c636c13 |
| Source note | uspto-grants-2000_10 |