反应详情

Prepared according to the method described in Example 4(b) above from Nα -Boc-Nδ -Cbz-(R)-ornithine o-nitrophenyl ester (4.0 g; 9.22 mmol; see Example 4(a) above) and (S)-(+)-phenylglycinol (1.26 g; 9.22 mmol; 1 eq.) and CH2Cl2 (160 mL). The reaction mixture was stirred overnight and then washed with saturated aqueous KHSO4, saturated aqueous Na2CO3, brine, dried with Na2SO4, filtered and concentrated to dryness. The residue was triturated with ether to obtain 3.8 g of the sub-title compound as a white solid.

1. customPrepared
2. washwashed with saturated aqueous KHSO4, saturated aqueous Na2CO3, brine
3. dry with materialdried with Na2SO4
4. filtrationfiltered
5. concentrationconcentrated to dryness
6. customThe residue was triturated with ether