Triethylamine → (R)-N5-(Cbz)-N2-(Diphenylacetyl)-(S)-N-(2-hydroxy-1-phenylethyl)-ornithine amide

Participants

Reaction Steps

Prepared according to the method described in Example 1(d) above from (R)-N5 -(Cbz)-(S)-N-(2-hydroxy-1-phenylethyl)ornithine amide hydrochloride (2.0 g, 4.74 mmol; from step (b) above), 2-nitrophenyl diphenyl acetate (1.67 g; 5.21 mmol; see Example 1(c) above) and triethylamine (0.726 mL; 5.21 mmol) in 150 mL of CH2Cl2. The reaction mixture was heated to reflux for 1 hour, followed by standard aqueous work up, yielding 1.78 g of the sub-title compound as a white solid.

Provenance & Evidence