HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-beta-aminophenethyl alcohol → (R)-N2-(Boc)-N5-(Cbz)-(R)-N-(2-Hydroxy-1-phenylethyl)ornithine amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-beta-aminophenethyl alcohol | HCID 2724025 | — |
| Reactant | Nalpha-Boc-Ndelta-Cbz-(R)-ornithine o-nitrophenyl ester | HCID 54461433 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (R)-N2-(Boc)-N5-(Cbz)-(R)-N-(2-Hydroxy-1-phenylethyl)ornithine amide | HCID 131722061 | 69.8% |
Reaction Steps
Prepared according to the method described in Example 4(b) above from Nα -Boc-Nδ -Cbz-(R)-ornithine o-nitrophenyl ester (5.0 g; 11.5 mmol; see Example 4(a) above), (R)-(-)-phenylglycinol (1.58 g; 11.5 mmol) and 160 mL of CH2Cl2, yielding 3.9 g of the sub-title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06127414 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-92e6a83c76064f25a849826c350fee0d |
| Source note | uspto-grants-2000_10 |