HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (R)-N2-(Diphenylacetyl)-(R)-N-(2-hydroxy-1-phenylethyl)ornithine amide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (R)-N5-(Cbz)-N2-(Diphenylacetyl)-(R)-N-(2-hydroxy-1-phenylethyl)-ornithine amide | HCID 131722064 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (R)-N2-(Diphenylacetyl)-(R)-N-(2-hydroxy-1-phenylethyl)ornithine amide hydrochloride | HCID 131722065 | — |
Reaction Steps
Prepared according to the method described in Example 1(e) above from a batch of (R)-N5 -(Cbz)-N2 -(diphenylacetyl)-(R)-N-(2-hydroxy-1-phenyl-ethyl)ornithine amide (2.5 g; from step (c) above), 10% Pd/C (200 mg), 100 mL of MeOH and 1.0 mL of concentrated HCl, yielding 1.8 g of the sub-title compound as a white foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06127414 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-cd655eddf2fc4612b9f385b09b07827b |
| Source note | uspto-grants-2000_10 |