Hydrogen chloride-ethyl acetate → (R)-N5-(Cbz)-(S)-N-[2-hydroxy-1-(4-methoxyphenyl)ethyl]-ornithine amide hydrochloride

Participants

Reaction Steps

Prepared according to the method described in Example 1(b) above from crude (R)-N2 -(Boc)-N5 -(Cbz)-(S)-N-[2-hydroxy-l-(4-methoxyphenyl)ethyl]-ornithine amide (4.0 g; from step (a) above), EtOAc (100 mL) and HCl/EtOAc (100 mL), 18 hours reaction time. The hydrochloride salt was precipitated by the addition of diethyl ether, collected and dried to give the sub-title compound as a white solid (2.3 g).

Provenance & Evidence