Hydrogen chloride-ethyl acetate → (R)-N5-(Cbz)-(R)-N-[2-hydroxy-1-(4-methoxyphenyl)ethyl]ornithine amide hydrochloride

Participants

Reaction Steps

Prepared according to the method described in Example 1(b) above from crude (R)-N2 -(Boc)-N5 -(Cbz)-(R)-N-[2-hydroxy-1-(4-methoxyphenyl)-ethyl]ornithine amide (3.7 g; from step (a) above), EtOAc (100 mL) and HCl/EtOAc (100 mL), 18 hours reaction time. The solution was concentrated to give the crude sub-title compound as a yellow crushable foam (3.3 g) which was used without purification.

Provenance & Evidence