HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 178490624, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1,3-Bis(benzyloxycarbonyl)-2-methylisothiourea | HCID 4664213 | — |
| Reactant | (R)-N2-(Diphenylacetyl)-(R)-N-[2-hydroxy-1-(4-methoxyphenyl)ethyl]-ornithine amide hydrochloride | HCID 131722079 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178490624 | HCID 178490624 | 55% |
Reaction Steps
Prepared according to the method described in Example 4(f) above from (R)-N2 -(diphenylacetyl)-(R)-N-[2-hydroxy-1-(4-methoxyphenyl) ethyl]ornithine amide hydrochloride (0.57 g; 1.11 mmol; from step (d) above), N,N'-bis(Cbz)-S-methylisothiourea (0.44 g; 1.22 mmol), triethylamine (0.17 g; 1.67 mmol; instead of DiPEA) and dimethyl formamide (10 mL), 60 hours reaction time. Concentration under vacuum gave the crude product which was chromatographed on silica eluting with CH2Cl2 :EtOAc (3:1), then CH2Cl2 :EtOAc (1:1), to give pure sub-title compound as a solid (0.48 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06127414 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-c80b30a89fe749b6bc9e78fa173b7976 |
| Source note | uspto-grants-2000_10 |