HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen chloride-ethyl acetate → (R)-N5-(Cbz)-(S)-N-[1-(4-hydroxyphenyl)ethyl]ornithine amide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen chloride-ethyl acetate | HCID 21866389 | — |
| Reactant | (R)-N2-(Boc)-N5-(Cbz)-(S)-N-[1-(4-hydroxyphenyl)ethyl]ornithine amide | HCID 86755920 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (R)-N5-(Cbz)-(S)-N-[1-(4-hydroxyphenyl)ethyl]ornithine amide hydrochloride | HCID 86755918 | — |
Reaction Steps
Prepared according to the method described in Example 1(b) above from (R)-N2 -(Boc)-N5 -(Cbz)-(S)-N-[1-(4-hydroxyphenyl)ethyl]ornithine amide (5.1 g; from step (a) above), ethyl acetate (100 mL) and HCl/EtOAc (100 mL) yielding, after isolation, 3.3 g of the sub-title compound as a tan solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06127414 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-c7fc325e3e4f41df917ad49949ed72a3 |
| Source note | uspto-grants-2000_10 |