(R)-N5-(Cbz)-N2-(Diphenylacetyl)-N-methyl-(R)-N-(1-phenylethyl)ornithine amide → (R)-N2-(Diphenylacetyl)-N-methyl-(R)-N-(1-phenylethyl)ornithine amide

Participants

Reaction Steps

Prepared according to the method described in Example 1(e) above from (R)-N5 -(Cbz)-N2 -(diphenylacetyl)-N-methyl-(R)-N-(1-phenylethyl)ornithine amide (1.6 g; 2.8 mmol; from step (b) above), 10% Pd/C (w/w; 100 mg), HOAc (75 mL), overnight reaction time. The crude acetate salt was purified by chromatography on silica gel with EtOAc, then CHCl3 :MeOH:concentrated ammonium hydroxide (6:3:1) to provide 1.2 g (98%) of the sub-title compound.

Provenance & Evidence