Nalpha-Boc-Ndelta-Cbz-(R)-ornithine o-nitrophenyl ester → (R)-N2-(Boc)-N5-(Cbz)-(R)-N-[1-(4-Benzyloxyphenyl)ethyl]ornithine amide

関与物質

反応手順

Prepared according to the method described in Example 4(b) above from Nα -Boc-Nδ -Cbz-(R)-ornithine-o-nitrophenyl ester (3.11 g; 6.37 mmol), (R)-4-benzyloxy-α-methylbenzylamine hydrochloride (1.68 g; 6.37 mmol), TEA (1.94 g; 19.10 mmol) and CH2Cl2 (200 mL), 18 hours reaction time. The resultant yellow solution was concentrated to afford the crude sub-title compound which was used directly in the next step.

情報源と証拠