Hydrogen chloride-ethyl acetate → (R)-N5-(Cbz)-(R)-N-[1-(4-Benzyloxyphenyl)ethyl]ornithine amide hydrochloride

Participants

Reaction Steps

Prepared according to the method described in Example 1(b) above from crude (R)-N2 -(Boc)-N5 -(Cbz)-(R)-N-[1-(4-benzyloxyphenyl)ethyl]-ornithine amide (6.37 mmol; from step (a) above), EtOAc (200 mL) and HCl/EtOAc (75 mL), 3 hours reaction time. The resultant heterogeneous solution was concentrated to 100 mL, slurried with Et2O and the solids collected and dried to afford the sub-title compound as a white solid (2.5 g; 75%).

Provenance & Evidence