Trimethylsilyl iodide → HCID 131722099, compound

Participants

Reaction Steps

Prepared according to the method described in Example 6(d) above from (R)-N5 -(Cbz)-N2 -(diphenylacetyl)-(R)-N-[1-(1-naphthyl)ethyl]ornithine amide (1.0 g; 1.63 mmol; from step (c) above), trimethylsilyliodide (0.36 g, 1.79 mmol) and CH3CN (60 mL) at 0° C., 3.5 hours reaction time. The resultant heterogeneous solution was submitted to aqueous work up and chromatographed on silica eluting with CH2Cl2 :MeOH:conc. NH4OH (88.5:10:1.5) to afford the sub-title compound as a solid (0.5 g).

Provenance & Evidence