Pyrazole-1-carboxamidine monohydrochloride → HCID 178462149, compound

Participants

Reaction Steps

Prepared according to the method described in Example 6(e) above from (R)-N2 -(diphenylacetyl)-(R)-N-[1-(1-naphthyl)ethyl]ornithine amide (0.42 g; 0.88 mmol; step (d) above), 1H-pyrazole-1-carboxamidine mono-hydrochloride (0.14 g; 0.88 mmol), TEA (0.18 g; 1.76 mmol) and DMF (8 mL), 18 hours reaction time. The resultant solution was concentrated and chromatographed on silica eluting with MeOH:CHCl3 :conc. NH4OH (3:6:1) to afford the title compound as a white solid (0.38 g).

Provenance & Evidence